The current scientific consensus is that the universe came into being following an event known as the ‘Big Bang’. Matter expanded rapidly from an extremely hot, extremely dense state, having transmuted from pure energy. Matter and energy then sprang forth to form the universe as we know it. This conclusion is drawn by interpreting certain observed information, notably two phenomena, the cosmic microwave background and the red shift of distant objects.
If scientists are going to see scientific reductionism as a complete explanation of beginnings, to rid themselves of that word 'creation', then we will have to get beyond this point. I do not believe there are currently any meaningful leads on this one.